STELLARTAQ
DNA POLYMERASE
(Coming Soon)

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PCR Uninhibited

StellarTaq™ DNA Polymerase (DNAP) is engineered for extreme inhibitor tolerance, speed, and specificity. The polymerase catalyzes 5′ → 3′ DNA synthesis, has 5′ → 3′ exonuclease activity, and is deficient in 3′ → 5′ exonuclease activity making it suitable for probe digestion. It amplifies uracil-containing templates, incorporates modified bases, and performs A-tailing on DNA products. Available in hot start, non-hot start, and glycerol-free formats.

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Key Features and Benefits

  • Extreme inhibitor tolerance offers robust amplification across a range of clinical sample types, including urine, blood, sputum and bile
  • High speed enables fast PCR applications
  • Hot start mechanism ensures high specificity
  • Custom formats, including high concentrate and glycerol-free, support lyophilization
  • Cost-effective solution that delivers excellent performance
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ADLM 2024 poster: Purpose built reverse transcriptases and Taq DNA Polymerases deliver high yield in the presence of inhibitors

Applications

  • Pathogen detection
  • Infectious disease testing
  • Fast PCR
  • RT-qPCR
  • PCR amplification of DNA fragments ≤ 5 kb
  • Probe and intercalating dye-based qPCR
  • PCR applications where biological inhibitors are present and specificity is important

Key Performance Data

Extreme inhibitor tolerance

Inhibitors – ubiquitous in biological samples – can interfere with amplification, leading to inaccurate results and false negatives. Using an inhibitor-tolerant polymerase ensures reliable amplification even in the presence of challenging substances found in clinical samples, essential for accurate infectious disease testing. StellarTaq delivers leading inhibitor-tolerance to deliver accurate and reproducible results every time.

Figure 1. Enable amplification of challenging sample types with inhibitor-tolerant StellarTaq. A probe-based qPCR assay was employed in the presence of increasing inhibitors with wild-type (WT) Taq DNA Polymerase (DNAP), Competitor A engineered Taq, and StellarTaq DNAP. As the inhibitor cocktail concentration is increased, DNA yields decrease for WT Taq. In contrast, StellarTaq exhibits extreme inhibitor tolerance — retaining robust DNA amplification.
Extreme inhibitor tolerance
Figure 1. Enable amplification of challenging sample types with inhibitor-tolerant StellarTaq. A probe-based qPCR assay was employed in the presence of increasing inhibitors with wild-type (WT) Taq DNA Polymerase (DNAP), Competitor A engineered Taq, and StellarTaq DNAP. As the inhibitor cocktail concentration is increased, DNA yields decrease for WT Taq. In contrast, StellarTaq exhibits extreme inhibitor tolerance — retaining robust DNA amplification.
Figure 1. Enable amplification of challenging sample types with inhibitor-tolerant StellarTaq. A probe-based qPCR assay was employed in the presence of increasing inhibitors with wild-type (WT) Taq DNA Polymerase (DNAP), Competitor A engineered Taq, and StellarTaq DNAP. As the inhibitor cocktail concentration is increased, DNA yields decrease for WT Taq. In contrast, StellarTaq exhibits extreme inhibitor tolerance — retaining robust DNA amplification.
For assay developers – make realizing your next product easier
  • Navigate the complexities of productization with an experienced team who’s as committed to your success as you are
  • All aspects of our customization process are designed to serve you with speed, agility, and above all else, a commitment to quality
  • Tailored fill volumes, labeling (including white and private label), and packaging designed to your specifications
  • All products are manufactured within an ISO 13485:2016-certified QMS (download our certificate)

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Prevent RNA degradation during RNA isolation and cDNA synthesis, even at elevated temperatures. High-purity and cost-effective.
Contact us for more information or to sample