Watchmaker combines core competencies in computational biology, protein engineering and enzyme production to build high-performance, precision tools for emerging and high-throughput applications in genomics, molecular diagnostics, personalized medicine, and synthetic biology.

High-resolution, next-generation sequencing (NGS) applications drive the need for increasingly sophisticated sample preparation workflows to enable biologically meaningful measurements from a wide range of sample types and inputs. Our extensive experience with real-word challenges in inherited disease, somatic oncology, transcriptomics, and epigenomics allows us to purpose-design enzymes and workflows to address unmet needs related to throughput, consistency of supply, and performance. With valuable insights into the inefficiencies, biases, and artifacts resulting from enzymatic fragmentation of DNA, dsDNA ligation, and library amplification, we are able to effect specific and measurable performance improvements in NGS library construction with the ultimate goal of generating data outputs that are a perfect representation of information carried within biological samples.

Solutions by Product Portfolio


Equinox Library Amplification Kits

An ultra-high-fidelity DNA polymerase in an optimized hot start master mix format, specifically optimized for high-efficiency, low-bias NGS library amplification

Watchmaker DNA-Seq Solutions

Watchmaker DNA Library Prep Solutions

Rapid workflows to address all sample types and yield high conversion rates, reduced bias and artifacts, and reproducible results

Watchmaker RNA Library Prep Solutions

RNA Library Prep Solutions

Highly sensitive, scalable, and robust chemistry with respect to performance with challenging clinically relevant sample types, such as FFPE and low inputs

Watchmaker StellarScript Reverse Transcriptases Banner

Stellarscript Reverse Transcriptases

A portfolio of M-MLV RTase variants engineered for reduced RNase H activity, increased thermostability, improved processivity, and enhanced inhibitor tolerance
Watchmaker StellarScript Reverse Transcriptases Banner

Enzymes and Proteins

Purpose-built Enzymes and Proteins to address performance gaps in challenging molecular biology applications.

Solutions by Application

Whole Genome Sequencing

Whole Genome Sequencing

Scale easily and minimize bias with a high-efficiency DNA library prep solutions.

Single-cell Sequencing

Single-cell Sequencing

Save money on expensive single cell experiments with a cost-effective RNase Inhibitor and high-fidelity cDNA amplification reagents.

Clinically relevant sequencing

Clinically relevant sequencing

Sensitive applications require precision tools. Improve performance with FFPE and liquid biopsy samples with rapid solutions.

Watchmaker’s purpose-driven development approach
ensures the needs of rigorous and highly sensitive applications such as
rare variant detection, ctDNA analysis, transcriptomics, epigenetics, and single-cell assays are met.