Watchmaker combines core competencies in computational biology, protein engineering and enzyme production to build high-performance, precision tools for emerging and high-throughput applications in genomics, molecular diagnostics, personalized medicine, and synthetic biology.

High-resolution, next-generation sequencing (NGS) applications drive the need for increasingly sophisticated sample preparation workflows to enable biologically meaningful measurements from a wide range of sample types and inputs. Our extensive experience with real-word challenges in inherited disease, somatic oncology, transcriptomics, and epigenomics allows us to purpose-design enzymes and workflows to address unmet needs related to throughput, consistency of supply, and performance. With valuable insights into the inefficiencies, biases, and artifacts resulting from enzymatic fragmentation of DNA, dsDNA ligation, and library amplification, we are able to effect specific and measurable performance improvements in NGS library construction with the ultimate goal of generating data outputs that are a perfect representation of information carried within biological samples.


Equinox Library Amplification Kits

An ultra-high-fidelity DNA polymerase in an optimized hot start master mix format, specifically optimized for high-efficiency, low-bias NGS library amplification

Think Bigger; Go Beyond Party co-hosted with Element Biosciences

Watchmaker DNA Library Prep Kits with Fragmentation

A streamlined single-tube chemistry with reduced bias and artifacts. Ideally suited for PCR-free workflows, ultra-low inputs, and low-quality DNA samples including FFPE

Watchmaker RNA Library Prep Solutions

RNA Library Prep Solutions

Highly sensitive, scalable, and robust chemistry with respect to performance with challenging clinically relevant sample types, such as FFPE and low inputs

Watchmaker StellarScript Reverse Transcriptases Banner

Stellarscript Reverse Transcriptases

A portfolio of M-MLV RTase variants engineered for reduced RNase H activity, increased thermostability, improved processivity, and enhanced inhibitor tolerance

Watchmaker’s purpose-driven development approach
ensures the needs of rigorous and highly sensitive applications such as
rare variant detection, ctDNA analysis, transcriptomics, epigenetics, and single-cell assays are met.