Watchmaker combines core competencies in computational biology, protein engineering and enzyme production to build high-performance, precision tools for emerging and high-throughput applications in genomics, molecular diagnostics, personalized medicine, and synthetic biology.
High-resolution, next-generation sequencing (NGS) applications drive the need for increasingly sophisticated sample preparation workflows to enable biologically meaningful measurements from a wide range of sample types and inputs. Our extensive experience with real-word challenges in inherited disease, somatic oncology, transcriptomics, and epigenomics allows us to purpose-design enzymes and workflows to address unmet needs related to throughput, consistency of supply, and performance. With valuable insights into the inefficiencies, biases, and artifacts resulting from enzymatic fragmentation of DNA, dsDNA ligation, and library amplification, we are able to effect specific and measurable performance improvements in NGS library construction with the ultimate goal of generating data outputs that are a perfect representation of information carried within biological samples.
Solutions by Product Portfolio
Equinox® Library Amplification Kits
An ultra-high-fidelity DNA polymerase in an optimized hot start master mix format, specifically optimized for high-efficiency, low-bias NGS library amplification
Watchmaker DNA Library Prep Solutions
Rapid workflows to address all sample types and yield high conversion rates, reduced bias and artifacts, and reproducible results
RNA Library Prep Solutions
Highly sensitive, scalable, and robust chemistry with respect to performance with challenging clinically relevant sample types, such as FFPE and low inputs
StellarScript® Reverse Transcriptases
Enzymes and Proteins
Purpose-built Enzymes and Proteins to address performance gaps in challenging molecular biology applications.
Solutions by Application
Whole Genome Sequencing
Scale easily and minimize bias with a high-efficiency DNA library prep solutions.
Single-cell Sequencing
Save money on expensive single cell experiments with a cost-effective RNase Inhibitor and high-fidelity cDNA amplification reagents.
Clinically relevant sequencing
Sensitive applications require precision tools. Improve performance with FFPE and liquid biopsy samples with rapid solutions.
Watchmaker’s purpose-driven development approach
ensures the needs of rigorous and highly sensitive applications such as
rare variant detection, ctDNA analysis, transcriptomics, epigenetics, and single-cell assays are met.